1. How much tear fluid does TearPRO collect and how is it collected?

Schirmer test paper tear collection was performed by placing the Schirmer test paper at the junction of the middle and lateral thirds of the lower eyelid. The subjects were instructed to close their eyes for 5 min during which the collection took place. Capillary tube tear collection was carried out by placing a 100 mm length by 0.5 mm inner diameter capillary tube on the inferior meniscus under slit-lamp microscopy with soft illumination. Typically, 2–5 μl tears were collected within 2 min. Care was taken to avoid touching either the corneal or conjunctival surfaces.

2.

Diagnostic performance of a tear protein panel in early dry eye

Versura et al. – Molecular Vision – 2013

Quantification of tear proteins by SDS-PAGE with an internal standard protein: A new method with special reference to small volume tears

Li, K., Chen, Z., Duan, F., Liang, J., & Wu, K. -Graefe’s Archive for Clinical and Experimental Ophthalmology- 2010

Dry Eye and Clinical Disease of Tear Film – Diagnosis and Management

Chiva – European Ophthalmic Review – 2014

Tear Biomarkers in Dry Eye Disease

Chiva – European Ophthalmic Review – 2019